Early evaluation of treatment response and prediction of disease evolution are key issues in
the management of people with multiple sclerosis (MS). In the past 20 years, MRI has …

Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges,
including a lack of standardized imaging protocols. Here we present a prospectively …

Overactivation of microglia is associated with most neurodegenerative diseases. In this
study we examined whether PET-measurable innate immune cell activation predicts multiple …

Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying
degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to …

Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

Multiple sclerosis (MS) is a chronic disease with an inflammatory and neurodegenerative
pathology. Axonal loss and neurodegeneration occurs early in the disease course and may …

Objective In multiple sclerosis (MS), cerebral gray matter (GM) atrophy correlates more
strongly than white matter (WM) atrophy with disability. The corresponding relationships in …

ABSTRACT BACKGROUND AND PURPOSE Spinal cord atrophy (SCA) is an important
emerging outcome measure in multiple sclerosis (MS); however, there is limited consensus …

Background: Spinal cord pathology is an important substrate for long-term disability in
multiple sclerosis (MS). Objective: To investigate longitudinal changes in spinal cord lesions …

The spinal cord is frequently affected in multiple sclerosis (MS), causing motor, sensory and
autonomic dysfunction. A number of pathological abnormalities, including demyelination …