The 5′ N 7-methylguanosine cap is a critical modification for mRNAs and many other RNAs
in eukaryotic cells. Recent studies have uncovered an RNA 5′ capping quality surveillance …

Posttranslational modifications (PTMs) are covalent modifications of proteins that modulate
the structure and functions of proteins and regulate biological processes. The development …

On macroevolutionary timescales, extensive mutations and phylogenetic uncertainty mask
the signals of genotype–phenotype associations underlying convergent evolution. To …

We recently reported the presence of nicotinamide adenine dinucleotide (NAD)-capped
RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decapping …

Poly (ADP-ribose)(PAR) is a homopolymer of adenosine diphosphate ribose that is added to
proteins as a posttranslational modification to regulate numerous cellular processes. PAR …

Proteins of the NUDIX hydrolase (NUDT) superfamily that cleave organic pyrophosphates
are found in all classes of organisms, from archaea and bacteria to higher eukaryotes. In …

ADP-ribosylation is a key post-translational modification that regulates a wide variety of
cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers …

Various kinds of cap structures, such as m7G, triphosphate groups, NAD and dpCoA, protect
the 5′ terminus of RNA. The cap structures bond covalently to RNA and affect its stability …

Latest advancement of omics technologies allows in-depth characterization of venom
compositions. In the present work we present a proteomic study of two snake venoms of the …

Nudt16 is a member of the NUDIX family of hydrolases that show specificity towards
substrates consisting of a nucleoside diphosphate linked to another moiety X. Several …