Mammalian promoters belong to two different categories in terms of base composition and
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …

DNA replication is the process by which cells make one complete copy of their genetic
information before cell division. In bacteria, readily identifiable DNA sequences constitute …

Tumors with somatic mutations in the proofreading exonuclease domain of DNA polymerase
epsilon (POLE-exo*) exhibit a novel mutator phenotype, with markedly elevated TCT→ TAT …

The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and
proliferation and is broadly implicated in tumorigenesis. However, the biological functions …

In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle.
Their genomic organization and their genetic nature remain elusive. Here, we characterized …

To unveil the still-elusive nature of metazoan replication origins, we identified them genome-
wide and at unprecedented high-resolution in mouse ES cells. This allowed initiation sites …

Selection of active origins and regulation of interorigin spacing are poorly understood in
mammalian cells. Using tricolor analysis of combed DNA molecules, we studied an …

We report that a highly purified human origin recognition complex (HsORC) has intrinsic
DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds …

The mechanisms by which metazoan origins of DNA replication are defined, regulated, and
influenced by chromosomal events remain poorly understood. To gain insights into these …

Strict regulation of DNA replication is essential to ensure proper duplication and segregation
of chromosomes during the cell cycle, as its deregulation can lead to genomic instability and …