The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

The respiratory tract is a vital, intricate system for several important biological processes
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …

Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but
emergence of viral variants that are antigenically distinct from the vaccine strains are of …

Summary Alveolar epithelial type 2 (AT2) cells integrate signals from multiple molecular
pathways to proliferate and differentiate to drive regeneration of the lung alveolus. Utilizing …

Patients with permanent hypoparathyroidism require lifelong replacement therapy to avoid
life-threatening complications, The benefits of conventional treatment are limited, however …

A central question for regenerative neuroscience is whether synthetic neural circuits, such
as those built from two species, can function in an intact brain. Here, we apply blastocyst …

Growing human organs in animals sounds like something from the realm of science fiction,
but it may one day become a reality through a technique known as interspecies blastocyst …

Interspecies blastocyst complementation (IBC) provides a unique platform to study
development and holds the potential to overcome worldwide organ shortages. Despite …

Interspecies organ generation via blastocyst complementation has succeeded in rodents,
but not yet in evolutionally more distant species. Early developmental arrest hinders the …

Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential
for functional genomics and biomedical research, which require germline transmission for …