A roadmap towards improving outcomes in multiple myeloma

M Mohty, T Facon, F Malard, JL Harousseau - Blood Cancer Journal, 2024 - nature.com
Multiple myeloma (MM) is a chronic hematologic malignancy that remains incurable,
because most patients eventually relapse or become refractory to current treatments. MM is …

Hematological malignancies in older patients: Focus on the potential role of a geriatric assessment management

S Caserta, G Cancemi, S Loreta, A Allegra, F Stagno - Diagnostics, 2024 - mdpi.com
Geriatric assessment management is a multidimensional tool used to evaluate prognosis for
clinical outcomes and targets for interventions in older adults with cancer receiving …

[HTML][HTML] Cellular therapies in older adults with hematological malignancies: A case-based, state-of-the-art review

NR Neuendorff, A Khan, F Ullrich, S Yates… - Journal of Geriatric …, 2024 - Elsevier
Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic
hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor-(CAR-) T cell …

[HTML][HTML] Cancer-specific mortality in multiple myeloma: a population-based retrospective cohort study

A McCurdy, H Seow, GP Pond, A Gayowsky… - …, 2023 - ncbi.nlm.nih.gov
Survival has improved in patients diagnosed with multiple myeloma (MM) over the last two
decades; however, there remains a paucity of data on the causes of death in MM patients …

[HTML][HTML] Recommendations for the effective use of T-cell–redirecting therapies: a Canadian consensus statement

G Lancman, K Song, D White, T Crosbie… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Background T-cell–redirecting therapies, such as bispecific antibodies and chimeric antigen
receptor T-cells, exploit the cytotoxic capabilities of the immune system to destroy cells …

Personalized Treatment of Multiple Myeloma in Frail Patients

JJ Lipof, N Abdallah, B Lipe - Current Oncology Reports, 2024 - Springer
Abstract Purpose of Review As the treatment landscape for multiple myeloma (MM)
continues to expand at a rapid pace, management of older adults and frail patients becomes …

MRD negativity: considerations for older adults with multiple myeloma

H Mian, TM Wildes, CP Venner, R Fonseca - Blood cancer journal, 2023 - nature.com
Minimal (or measurable) residual disease (MRD) negativity has emerged as one of the most
important prognostic tools in multiple myeloma (MM) and is associated with significant …

Cumulative Deficits Frailty Index and Relationship Status Predict Survival in Multiple Myeloma

N Abdallah, P Dizona, A Kumar, B LaPlant, T Menser… - Blood Advances, 2024 - Elsevier
Several tools have been proposed for assessing frailty in multiple myeloma (MM), but most
are based on clinical trial datasets. There is also limited data on the association between …

LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473

Y Zhang, J Qian, M Jiang, S Yang, L Zhou… - Frontiers in …, 2023 - frontiersin.org
Multiple myeloma (MM) is a highly heterogeneous hematological malignancy originating
from B lymphocytes, with a high recurrence rate primarily due to drug resistance. 2-((1H …

A Simple Frailty Score Predicts Survival and Early Mortality in Systemic AL Amyloidosis

R Ríos-Tamayo, R Lecumberri, MT Cibeira… - Cancers, 2024 - mdpi.com
Simple Summary Despite a lack of standardization and some open questions, a growing
body of evidence supports the use of frailty to optimize the clinical management of patients …