Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

Alpha-synuclein is a small neuronal protein that is closely associated with the etiology of
Parkinson's disease. Mutations in and alterations in expression levels of alpha-synuclein …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Current research efforts on neurological diseases are focused on identifying novel disease
biomarkers to aid in diagnosis, provide accurate prognostic information and monitor disease …

Importance Identifying genes and proteins for cognitive resilience (ie, targets that may be
associated with slowing or preventing cognitive decline regardless of the presence, number …

In this article, we have characterized and compared gene expression profiles from laser
capture microdissected neurons in six functionally and anatomically distinct regions from …

Introduction Our objective was to compare the levels of three synaptic proteins involved in
different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three …

Parkinson disease (PD) is no longer considered a complex motor disorder characterized by
parkinsonism but rather a systemic disease with variegated non-motor deficits and …

In neurodegenerative diseases, seeding is a process initiated by the internalization of
exogenous protein aggregates. Multiple pathways for internalization of aggregates have …

Brain banks are facilities providing an interface between generous donation of nervous
tissues and research laboratories devoted to increase our understanding of the diseases of …