Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Circuit organization of the rodent medial prefrontal cortex

PG Anastasiades, AG Carter - Trends in neurosciences, 2021 - cell.com
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …

PV interneurons: critical regulators of E/I balance for prefrontal cortex-dependent behavior and psychiatric disorders

BR Ferguson, WJ Gao - Frontiers in neural circuits, 2018 - frontiersin.org
Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle

GMG Shepherd, N Yamawaki - Nature Reviews Neuroscience, 2021 - nature.com
Functions of the neocortex depend on its bidirectional communication with the thalamus, via
cortico-thalamo-cortical (CTC) loops. Recent work dissecting the synaptic connectivity in …

The cognitive thalamus as a gateway to mental representations

M Wolff, SD Vann - Journal of Neuroscience, 2019 - Soc Neuroscience
Historically, the thalamus has been viewed as little more than a relay, simply transferring
information to key players of the cast, the cortex and hippocampus, without providing any …

Cortico-striatal-thalamic loop circuits of the salience network: a central pathway in psychiatric disease and treatment

SK Peters, K Dunlop, J Downar - Frontiers in systems neuroscience, 2016 - frontiersin.org
The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

TVP Bliss, GL Collingridge, BK Kaang… - Nature Reviews …, 2016 - nature.com
The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this
Review, we discuss increasing evidence from rodent studies that ACC activation contributes …

Thalamic projections sustain prefrontal activity during working memory maintenance

SS Bolkan, JM Stujenske, S Parnaudeau… - Nature …, 2017 - nature.com
The mediodorsal thalamus (MD) shares reciprocal connectivity with the prefrontal cortex
(PFC), and decreased MD–PFC connectivity is observed in schizophrenia patients. Patients …

Where is cingulate cortex? A cross-species view

S van Heukelum, RB Mars, M Guthrie… - Trends in …, 2020 - cell.com
To compare findings across species, neuroscience relies on cross-species homologies,
particularly in terms of brain areas. For cingulate cortex, a structure implicated in behavioural …

Thalamic regulation of switching between cortical representations enables cognitive flexibility

RV Rikhye, A Gilra, MM Halassa - Nature neuroscience, 2018 - nature.com
Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …