The developing human fetus generates both tolerogenic and protective immune responses
in response to the unique requirements of gestation. Thus, a successful human pregnancy …

The concerted interaction of genetic and environmental factors acts on the preterm human
immature lung with inflammation being the common denominator leading to the …

Rationale: Mesenchymal stem/stromal cell (MSC) therapies have shown promise in
preclinical models of pathologies relevant to newborn medicine, such as bronchopulmonary …

Importance Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity,
remains one of the major and most common complications of very preterm birth. Insight into …

Exposure to hyperoxia, invasive mechanical ventilation, and systemic/local sepsis are
important antecedents of postnatal inflammation in the pathogenesis of bronchopulmonary …

Little evidence is available to document that mechanical ventilation is an antecedent of
systemic inflammation in preterm humans. We obtained blood on postnatal day 14 from 726 …

Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been linked to
the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication …

Background Preterm birth preceded by spontaneous preterm labour often occurs in the
clinical setting of sterile intra-amniotic inflammation (SIAI), a condition that currently lacks …

Pulmonary hypertension (PH) is an increasingly recognized complication of premature birth
and bronchopulmonary dysplasia (BPD), and is associated with increased morbidity and …

Even with advances in the care of preterm infants, chronic lung disease or
bronchopulmonary dysplasia (BPD) continues to be a significant pulmonary complication …