Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive
oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor …

Accurate descriptions of protein-protein interactions are essential for understanding
biological systems. Remarkably accurate atomic structures have been recently computed for …

Goats are useful to smaller communities because of their low production costs, limited feed
requirements, rapid generation rates, and ability to consistently provide modest volumes of …

Heme, an essential molecule for virtually all living organisms, acts primarily as a cofactor in
a large number of proteins. However, how heme is mobilized from the site of synthesis to the …

Mono-and multiheme cytochromes c are post-translationally matured by the covalent
attachment of heme. For this, Escherichia coli employs the most complex type of maturation …

Cytochromes c use heme as a cofactor to carry electrons in respiration and photosynthesis.
The cytochrome c maturation system I, consisting of eight membrane proteins …

Heme trafficking is a fundamental biological process, yet its direct study has been hampered
due to heme's tight intracellular regulation, heme cytotoxicity, and the transient nature of …

Heme trafficking is essential for cellular function, yet mechanisms of transport and/or heme
interaction are not well defined. The System I and System II bacterial cytochrome c …

Nitrite and nitric oxide (NO) are well-known bacteriostatic agents with similar biochemical
properties. However, many studies have demonstrated that inhibition of bacterial growth by …

Cytochrome c (Cytc) is a key redox protein for energy metabolism and apoptosis in cells.
The activation of Cytc is composed of several steps, including its transfer to the …