The optimal level of immunosuppression in solid organ transplantation, in particular for the
liver, is a delicate balance between the benefit of preventing rejection and the adverse side …

Effective immunosuppression is an essential pre-requisite for successful organ
transplantation and improvements in outcome after transplantation have to a large extent …

Importance Sirolimus is increasingly being used to treat various vascular anomalies,
although evidence of its efficacy is lacking. Objective To assess the efficacy and safety of …

Background Angiomyolipomas in patients with the tuberous sclerosis complex or sporadic
lymphangioleiomyomatosis are associated with mutations in tuberous sclerosis genes …

In a prospective, multicenter, open-label study, de novo liver transplant patients were
randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC …

The increasing potency of immunosuppression (IS) agents resulted in significantly
decreased rates of steroid resistant rejection and rejection related graft loss in liver …

Liver transplantation is an important treatment option for selected patients with
nonresectable hepatocellular carcinoma (HCC). Several reports have suggested a lower …

Despite recent advances in the understanding of the biologic basis of hepatocellular
carcinoma (HCC) development, the clinical management of the disease remains a major …

Background: The calcineurin inhibitors (CNIs), cyclosporine and tacrolimus, have had a
revolutionary effect on the overall success of renal transplantation through reduction in early …

Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor that inhibits cell cycle
progression and has proven to be a potent immunosuppressive agent for use in solid organ …