Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration
NH Shah, E Aizenman - Translational stroke research, 2014 - Springer
Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …
nervous system and are crucial mediators of neuronal excitability. Importantly, these …
Voltage-gated potassium channels as regulators of cell death
Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …
The genetic landscape of infantile spasms
JL Michaud, M Lachance, FF Hamdan… - Human molecular …, 2014 - academic.oup.com
Infantile spasms (IS) is an early-onset epileptic encephalopathy of unknown etiology in∼
40% of patients. We hypothesized that unexplained IS cases represent a large collection of …
40% of patients. We hypothesized that unexplained IS cases represent a large collection of …
Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain
Injury, inflammation, and nerve damage initiate a wide variety of cellular and molecular
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …
[HTML][HTML] Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery
Stroke is the leading cause of death and disability. Currently, there is no effective
pharmacological treatment for this disease, which can be partially attributed to the inability to …
pharmacological treatment for this disease, which can be partially attributed to the inability to …
Spectrum of KV2.1 Dysfunction in KCNB1‐Associated Neurodevelopmental Disorders
SK Kang, CG Vanoye, SN Misra… - Annals of …, 2019 - Wiley Online Library
Objective Pathogenic variants in KCNB1, encoding the voltage‐gated potassium channel
KV2. 1, are associated with developmental and epileptic encephalopathy (DEE). Previous …
KV2. 1, are associated with developmental and epileptic encephalopathy (DEE). Previous …
Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents
MC McCord, E Aizenman - Proceedings of the National …, 2013 - National Acad Sciences
A simultaneous increase in cytosolic Zn2+ and Ca2+ accompanies the initiation of neuronal
cell death signaling cascades. However, the molecular convergence points of cellular …
cell death signaling cascades. However, the molecular convergence points of cellular …
SP6616 as a Kv2. 1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice
X Zhu, Y Chen, X Xu, X Xu, Y Lu, X Huang, J Zhou… - …, 2020 - thelancet.com
Background Diabetic peripheral neuropathy (DPN) is a common complication of diabetes
severely afflicting the patients, while there is yet no effective medication against this disease …
severely afflicting the patients, while there is yet no effective medication against this disease …
Sensory neuron dysfunction in orthotopic mouse models of colon cancer
Reports of neurological sequelae related to colon cancer are largely restricted to rare
instances of paraneoplastic syndromes, due to autoimmune reactions. Systemic …
instances of paraneoplastic syndromes, due to autoimmune reactions. Systemic …
Targeting a potassium channel/syntaxin interaction ameliorates cell death in ischemic stroke
The voltage-gated K+ channel Kv2. 1 has been intimately linked with neuronal apoptosis.
After ischemic, oxidative, or inflammatory insults, Kv2. 1 mediates a pronounced, delayed …
After ischemic, oxidative, or inflammatory insults, Kv2. 1 mediates a pronounced, delayed …