Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Both environmental and genetic triggers factor into the etiology of autoimmune thyroid
disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT). Although …

The immunosuppressive function of regulatory B cells has been shown in several murine
models of chronic inflammation, including collagen-induced arthritis, inflammatory bowel …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

The failure of many new, mostly biologic, drugs to meet their primary end points in double-
blind clinical trials in patients with systemic lupus erythematosus (SLE) has caused a …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Abstract Objective CD40–CD40 ligand (CD40L) interactions play a significant role in the
production of autoantibodies and tissue injury in lupus nephritis. We performed an open …