Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization

M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …

Genetic engineering as a strategy to improve the therapeutic efficacy of mesenchymal stem/stromal cells in regenerative medicine

PKF Damasceno, TSA De Santana… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stem/stromal cells (MSCs) have been widely studied in the field of
regenerative medicine for applications in the treatment of several disease settings. The …

Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI

X Ai, B Yan, N Witman, Y Gong, L Yang, Y Tan… - Molecular Therapy, 2023 - cell.com
Cell-based therapies offer an exciting and novel treatment for heart repair following
myocardial infarction (MI). However, these therapies often suffer from poor cell viability and …

The beneficial effects of mesenchymal stem cells and their exosomes on myocardial infarction and critical considerations for enhancing their efficacy

M Ala - Ageing Research Reviews, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent stromal cells with regenerative, anti-
inflammatory, and immunomodulatory properties. MSCs and their exosomes significantly …

Functionally improved mesenchymal stem cells to better treat myocardial infarction

Z Chen, L Chen, C Zeng, WE Wang - Stem cells international, 2018 - Wiley Online Library
Myocardial infarction (MI) is one of the leading causes of death worldwide. Mesenchymal
stem cell (MSC) transplantation is considered a promising approach and has made …

Anti-fibrotic mechanisms of exogenously-expanded mesenchymal stromal cells for fibrotic diseases

JS Rockel, R Rabani, S Viswanathan - Seminars in cell & developmental …, 2020 - Elsevier
Most chronic diseases involving inflammation have a fibrotic component that involves
remodeling and excess accumulation of extracellular matrix components. Left unchecked …

Efficacy of stem cell therapy in large animal models of ischemic cardiomyopathies: A systematic review and meta-analysis

D La Mantia, C Bernardini, A Zannoni, R Salaroli… - Animals, 2022 - mdpi.com
Simple Summary The present work focuses on stem-cell assessment as a therapeutic
approach on cardiovascular diseases, both in terms of safety and efficacy. In particular, this …

Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions

LB Gallagher, EB Dolan, J O'Sullivan, R Levey… - Acta biomaterialia, 2020 - Elsevier
The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has
been proposed to promote cell adhesion to the matrix, which can influence and control cell …

[HTML][HTML] Lentiviral vector-mediated co-overexpression of VEGF and Bcl-2 improves mesenchymal stem cell survival and enhances paracrine effects in vitro

X Ni, C Ou, J Guo, B Liu, J Zhang… - International …, 2017 - spandidos-publications.com
Mesenchymal stem cell (MSC) transplantation has emerged as a promising therapy for
ischemic heart disease; however, the low survival rate of transplanted cells limits their …

Pre-culture in endothelial growth medium enhances the angiogenic properties of adipose-derived stem/stromal cells

LEB Souza, LR Beckenkamp, LM Sobral… - Angiogenesis, 2018 - Springer
Considerable progress has been made on the development of adipose-derived
stem/stromal cells (ASCs) as pro-angiogenic therapeutic tools. However, variable clinical …