Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …

For almost a century, vitamin A has been known as a nutrient critical for normal
development, differentiation, and homeostasis; accordingly, there has been much interest in …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Oxidative stress is characterized by an imbalance between prooxidant and antioxidant
species, leading to macromolecular damage and disruption of redox signaling and cellular …

Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in
a screen for endogenous ligands for the cannabinoid receptor. The structure of this …

Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

The nuclear receptor superfamily is comprised of over 150 different proteins that have
evolved to mediate a complex array of extracellular signals into transcriptional responses …

Retinoids play an important role in development, differentiation, and homeostasis. The
discovery of retinoid receptors belonging to the superfamily of nuclear ligand‐activated …

Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is
essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted …