Chronic heart failure (CHF) impairs critical structural and functional components of the O2
transport pathway resulting in exercise intolerance and, consequently, reduced quality of …

In mammalian cells, mitochondria are the only organelles besides the nucleus that house
genomic DNA. The mammalian mitochondrial genome is represented by prokaryotic-type …

The negative relationship between testosterone and inflammatory cytokines has been
reported for decades, although the exact mechanisms of their interactions are still not clear …

Endurance training enhances mitochondrial oxidative capacity, but its effect on mitochondria
functioning is poorly understood. In the present study, the influence of an 8-week endurance …

Mitochondrial respiratory and phosphorylation activities, mitochondrial uncoupling, and
hydrogen peroxide formation were studied in isolated rat skeletal muscle mitochondria …

The aim of the present study was to examine whether improvements in pulmonary oxygen
uptake (V̇o2) kinetics following a short period of high-intensity training (HIT) would be …

Although aging has been associated to slower V˙ O2 kinetics, some evidence indicates that
fitness status and not aging per se might modulate this response. The main goal of this study …

Purpose Endurance training improves running performance in distances where oxidative
phosphorylation (OXPHOS) is the main ATP source. Here, a dynamic computer model is …

Computer simulations, using the “Pi double-threshold” mechanism of muscle fatigue
postulated previously (the first threshold initiating progressive reduction in work efficiency …

The activity and quantity of mitochondrial proteins and the mitochondrial volume density
(MitoVD) are higher in trained muscles; however, the underlying mechanisms remain …