▪ Abstract At the interface between the innate and adaptive immune systems lies the high-
output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine …

Nitric oxide synthases (NOSs)'(L-arginine, NADPH: oxygen oxidoreductases (nitric oxide
forming); EC 1.14. 13.39) are unique among eukaryotic enzymes in being dimeric …

The induction of optimal systemic antitumor immunity involves the priming of both CD4+ and
CD8+ T cells specific for tumor-associated antigens. The role of CD4+ T helper cells (Th) in …

Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules
known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from …

Atherosclerosis is an inflammatory disease. Its lesions are filled with immune cells that can
orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis …

Activated murine macrophages metabolize l-arginine via two main pathways that are
catalyzed by the inducible enzymes nitric oxide synthase (iNOS) and arginase. We have …

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent nuclear
receptor that has been implicated in the modulation of critical aspects of development and …

Activation with lipopolysaccharide induces macrophages to produce the enzymes arginase
and nitric oxide (NO) synthase. Both enzymes use as a substrate the amino acid L‐arginine …

The formation of nitric oxide (NO) from L‐arginine is now recognized as a ubiquitous
biochemical pathway involved in the regulation of the cardiovascular, central, and peripheral …

Accumulation of T cells and macrophages in atherosclerotic plaques and the formation of
antibodies directed against plaque proteins suggests that adaptive immunity contributes to …