Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Articular cartilage serves as a low-friction, load-bearing tissue without the support with blood
vessels, lymphatics and nerves, making its repair a big challenge. Transforming growth …

Nowadays, biomaterials have evolved from the inert supports or functional substitutes to the
bioactive materials able to trigger or promote the regenerative potential of tissues. The …

Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

The regeneration of 3D tissue constructs with clinically relevant sizes, structures, and
hierarchical organizations for translational tissue engineering remains challenging. 3D …

Articular cartilage defects bring about disability and worldwide socioeconomic loss,
therefore, articular cartilage repair and regeneration is recognized as a global issue …

Abstract 3D bioprinting is a promising strategy to develop heterogeneous constructs that
mimic osteochondral tissue. However, conventional bioprinted hydrogels suffer from …

Viscoelastic hydrogels can enhance 3D cell migration and proliferation due to the faster
stress relaxation promoting the arrangement of the cellular microenvironment. However …

Damage to cartilage tissues is often difficult to repair owing to chronic inflammation and a
lack of bioactive factors. Therefore, developing bioactive materials, such as hydrogels acting …

Tissue damage due to cancer, congenital anomalies, and injuries needs new efficient
treatments that allow tissue regeneration. In this context, tissue engineering shows a great …