Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

The progression of tuberculosis from a latent, subclinical infection to active disease that
culminates in the transmission of infectious bacilli is determined locally at the level of the …

Despite the development of potentially curative chemotherapy, tuberculosis (TB) continues
to cause increasing worldwide morbidity and is a leading cause of human mortality in the …

Tuberculosis (TB) is characterized by a tight interplay between Mycobacterium tuberculosis
and host cells within granulomas. These cellular aggregates restrict bacterial spreading, but …

One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

Granulomas are organized aggregates of macrophages, often with characteristic
morphological changes, and other immune cells. These evolutionarily ancient structures …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Fusion of macrophages leads to the formation of osteoclasts in bone and of multinucleated
giant cells in granulomas. The precise function of granuloma-associated multinucleates …

Mycobacterium tuberculosis is an old enemy of the human race, with evidence of infection
observed as early as 5000 years ago. Although more host-restricted than Mycobacterium …

Glycolipids, consisting of a carbohydrate moiety linked to fatty acids, are microbial surface
active compounds produced by various microorganisms. They are characterized by highly …