Predicting evolutionary change poses numerous challenges. Here we take advantage of the
model bacterium Pseudomonas fluorescens in which the genotype-to-phenotype map …

Evolutionary rescue describes a situation where adaptive evolution prevents the extinction
of a population facing a stressing environment. Models of evolutionary rescue could in …

All adaptive alleles in existence today began as mutations, but a common view in ecology,
evolution, and genetics is that non-neutral mutations are much more likely to be deleterious …

The effect of a mutation on fitness may differ between populations depending on
environmental and genetic context, but little is known about the factors that underlie such …

A common intuition among evolutionary biologists and ecologists is that environmental
stress will increase the strength of selection against deleterious alleles and among alternate …

Synaptic scaffold proteins control the localization of ion channels and receptors, and
facilitate molecular associations between signaling components that modulate synaptic …

The distribution of fitness effects (DFE) among new mutations plays a critical role in adaptive
evolution and the maintenance of genetic variation. Although fitness landscape models …

Genetic effects are often context dependent, with the same genotype differentially affecting
phenotypes across environments, life stages, and sexes. We used an environmental …

Understanding the origin, maintenance and distribution of nature's astonishing diversity of
reproductive systems is a major endeavour in evolutionary biology. One of the oldest …

Background Mutation accumulation (MA) has profound ecological and evolutionary
consequences. One example is that accumulation of conditionally neutral mutations leads to …