Extracellular vesicles as regulators of the extracellular matrix

NJ Patel, A Ashraf, EJ Chung - Bioengineering, 2023 - mdpi.com
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the
extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids …

Standardization approaches for extracellular vesicle loading with oligonucleotides and biologics

J Roerig, M Schulz‐Siegmund - Small, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are widely recognized for their potential as drug delivery
systems. EVs are membranous nanoparticles shed from cells. Among their natural features …

Engineering a tunable micropattern‐array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ

J Zhang, XY Rima, X Wang… - Journal of …, 2023 - Wiley Online Library
The molecular heterogeneity of extracellular vesicles (EVs) and the co‐isolation of
physically similar particles, such as lipoproteins (LPs), confounds and limits the sensitivity of …

Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages

P Pantazi, T Clements, M Venø… - Journal of …, 2022 - Wiley Online Library
Macrophages are important antigen presenting cells which can release extracellular
vesicles (EVs) carrying functional cargo including non‐coding RNAs. Macrophages can be …

Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications

T Williams, G Salmanian, M Burns, V Maldonado… - Biochimie, 2023 - Elsevier
Mesenchymal stem/stromal cells (MSCs) are multipotent somatic cells that have been widely
explored in the field of regenerative medicine. MSCs possess the ability to secrete soluble …

Circulating non-coding RNAs in chronic kidney disease and its complications

AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

A Al-Jipouri, À Eritja, M Bozic - International Journal of Molecular …, 2023 - mdpi.com
Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

CRISPR/Cas9 delivery strategies with engineered extracellular vesicles

Y Lu, K Godbout, G Lamothe, JP Tremblay - Molecular Therapy-Nucleic …, 2023 - cell.com
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic
mutations in tissues and cells. Recent progress in the clustered regularly interspaced short …

Extracellular vesicles-associated miRNAs in triple-negative breast cancer: From tumor biology to clinical relevance

FCB Berti, MV Tofolo, EN Souza, R Marchi, LM Okano… - Life Sciences, 2023 - Elsevier
Breast cancer (BC), a heterogeneous group of diseases, is the most frequent type and the
leading cause of cancer-related death among women worldwide. Tumor heterogeneity …

Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease

Y Couch - Expert Review of Molecular Diagnostics, 2023 - Taylor & Francis
Introduction The hunt for new biomarkers–for the diagnosis of subcategories of disease, or
for the monitoring of the efficacy of novel therapeutics–is an increasingly relevant challenge …