Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of
the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck …

Recent evidence suggests that complex karyotype (CK) defined by the presence of≥ 3
chromosomal aberrations (structural and/or numerical) identified by using chromosome …

Purpose: The oral BCL-2 inhibitor venetoclax is an effective therapy for patients with
relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), including disease with high …

Because atherosclerotic cardiovascular disease is a leading cause of death worldwide,
understanding inflammatory processes underpinning its pathology is critical. B cells have …

Background The prognosis of chronic lymphocytic leukemia (CLL) has been improved
dramatically, but there are limited studies focusing on CLL disease burden on a global …

Cancer cells must maintain metabolic homeostasis under a wide range of conditions and
meet their own energy needs in order to survive and reproduce. In addition to glycolysis …

Ibrutinib (Imbruvica®) is an oral irreversible inhibitor of Bruton's tyrosine kinase, a B-cell
receptor (BCR) signalling kinase expressed by various haematopoietic cells, B-cell …

Circular RNAs (circRNAs), a novel family of non-coding RNAs, play crucial roles in cancer
progression. While the existing research focuses on nuclear genome-derived (nu)-circRNAs …

Bruton tyrosine kinase (BTK) is a key kinase in the B cell antigen receptor signal
transduction pathway, which is involved in the regulation of the proliferation, differentiation …