Senescent cells play an important role in mammalian ageing and in the etiology of age-
related diseases. Treatment of mice with senolytics–drugs that selectively remove senescent …

The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component
that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The …

Stochastic gene expression leads to inherent variability in expression outcomes even in
isogenic single-celled organisms grown in the same environment. The Drop-Seq technology …

Genome instability is a hallmark of aging and contributes to age-related disorders such as
cancer and Alzheimer's disease. The accumulation of DNA damage during aging has been …

Application of microfluidic platforms facilitated high-precision measurements of yeast
replicative lifespan (RLS); however, comparative quantification of lifespan across strain …

A double-strand break (DSB) is one of the most deleterious forms of DNA damage. In
eukaryotic cells, two main repair pathways have evolved to repair DSBs, homologous …

To clarify the regulation of astragalus on the aging BMSCs model and the effect of
astragalus on Vitamin D (VD)-FGF23-Klotho axis. siRNA was used to interfere the …

The accumulation of protein damage is one of the major drivers of replicative ageing,
describing a cell's reduced ability to reproduce over time even under optimal conditions …

Aim: To investigate the systemic immune-inflammation index and prognostic immune
nutritional index in the prognostic evaluation of oral squamous cell carcinoma. Materials & …

An increase in cell size with age is a characteristic feature of replicative aging in budding
yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced …