Amyloid aggregation of α-synuclein (αS) is the hallmark of Parkinson's disease and other
synucleinopathies. Recently, Tau protein, generally associated with Alzheimer's disease …

Intrinsically disordered proteins (IDPs) represent a structural class of proteins that do not
have a well-defined, 3D fold in solution, and often have little secondary structure. To …

Most experimental methods for structural biology proceed in vitro and therefore the
contribution of the intracellular environment on protein structure and dynamics is absent …

Neurofibrillary tangles of the Tau protein and plaques of the amyloid β peptide are hallmarks
of Alzheimer's disease (AD), which is characterized by the conversion of monomeric …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of
extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) …

Intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of
Alzheimer's disease (AD), characterized by the conversion of natively unfolded monomeric …

Macroautophagy/autophagy receptors are essential for the recognition and clearance of
specific cargos by selective autophagy, which is essential for maintaining MAPT …

Polyphenols have been suggested as potential therapeutic agents for the treatment of
amyloidogenic diseases. In this work, we evaluate quercetin-rich onion extract for its ability …

Misfolding and accumulation of amyloidogenic proteins into various forms of aggregated
intermediates and insoluble amyloid fibrils is associated with more than 50 human diseases …

The human tau is a microtubule-associated intrinsically unstructured protein that forms
intraneuronal cytotoxic deposits in neurodegenerative diseases, like tauopathies. Recent …