Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing
neurological morbidity and mortality worldwide. In the pathophysiological process of IS …

Background Cerebral ischemia–reperfusion (I/R) injury is a major cause of early
complications and unfavorable outcomes after endovascular thrombectomy (EVT) therapy in …

Neuroinflammation is initiated in response to ischemic stroke, and is usually characterized
by microglial activation and polarization. Stimulator of interferon genes (STING) has been …

Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …

Microglial phagocytosis of apoptotic debris prevents buildup damage of neighbor neurons
and inflammatory responses. Whereas microglia are very competent phagocytes under …

Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Neuronal cells are highly functioning but also extremely stress-sensitive cells. By defending
the neuronal cells against pathogenic insults, microglial cells, a unique cell type, act as the …

Abstract Sestrin2 (SESN2), a highly conserved stress-responsive protein, can be triggered
by various noxious stimuli, such as hypoxia, DNA damage, oxidative stress, endoplasmic …

Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease with poor
prognosis. The intricacies surrounding its pathophysiology could partly account for the lack …