SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Sex determining region Y-box 2 (Sox2), a member of the SoxB1 transcription factor family, is
an important transcriptional regulator in pluripotent stem cells (PSCs). Together with octamer …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Pancreatic cancer (PC) is the fourth most common cause of death among all cancers. Poor
prognosis of PC may be caused by a prevalence of cancer stem cells (CSCs). CSCs are a …

Previous studies have demonstrated that the transcription factor Sox2 is essential during the
early stages of development. Furthermore, decreasing the expression of Sox2 severely …

Certain transcription factors are proposed to form functional interactions with RNA to
facilitate proper regulation of gene expression. Sox2, a transcription factor critical for …

Transcription factors are central to sustaining pluripotency, yet little is known about
transcription factor dynamics in defining pluripotency in the early mammalian embryo. Here …

Considerable progress has been made in understanding the roles of Sox2 and Oct4 in
embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has …

The Sox2 gene is a key regulator of pluripotency embedded within an intron of a long
noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed …

During the past 10 years, remarkable progress has been made in understanding the
transcriptional mechanisms that control the biology of stem cells. Given the importance of …