Myopia

PN Baird, SM Saw, C Lanca, JA Guggenheim… - Nature reviews Disease …, 2020 - nature.com
Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

IMI–Report on experimental models of emmetropization and myopia

D Troilo, EL Smith, DL Nickla, R Ashby… - … & visual science, 2019 - iovs.arvojournals.org
The results of many studies in a variety of species have significantly advanced our
understanding of the role of visual experience and the mechanisms of postnatal eye growth …

The sclera and myopia

JAS Rada, S Shelton, TT Norton - Experimental eye research, 2006 - Elsevier
Myopia is a very common ocular problem, affecting perhaps one billion people worldwide.
Most myopia is produced by lengthening of the vitreous chamber of the ocular globe. High …

Regulation of scleral metabolism in myopia and the role of transforming growth factor-beta

NA McBrien - Experimental eye research, 2013 - Elsevier
Myopia is one of the most prevalent ocular conditions and is the result of a mismatch
between the power of the eye and axial length of the eye. In the vast majority of cases the …

[HTML][HTML] Insight into the molecular genetics of myopia

J Li, Q Zhang - Molecular vision, 2017 - ncbi.nlm.nih.gov
Myopia is the most common cause of visual impairment worldwide. Genetic and
environmental factors contribute to the development of myopia. Studies on the molecular …

[HTML][HTML] Pharmacotherapeutic candidates for myopia: a review

WY Wang, C Chen, J Chang, L Chien, YF Shih… - Biomedicine & …, 2021 - Elsevier
This review provides insights into the mechanism underlying the pathogenesis of myopia
and potential targets for clinical intervention. Although the etiology of myopia involves both …

Investigating mechanisms of myopia in mice

MT Pardue, RA Stone, PM Iuvone - Experimental eye research, 2013 - Elsevier
Genetic and environmental factors have been shown to control visually-guided eye growth
and influence myopia development. However, investigations into the intersection of these …

[HTML][HTML] Functional integration of eye tissues and refractive eye development: Mechanisms and pathways

JA Summers, F Schaeffel, S Marcos, H Wu… - Experimental Eye …, 2021 - Elsevier
Refractive eye development is a tightly coordinated developmental process. The general
layout of the eye and its various components are established during embryonic …

Gene expression signatures in tree shrew choroid during lens-induced myopia and recovery

L He, MR Frost, JT Siegwart Jr, TT Norton - Experimental eye research, 2014 - Elsevier
Gene expression in tree shrew choroid was examined during the development of minus-lens
induced myopia (LIM, a GO condition), after completion of minus-lens compensation (a …

[HTML][HTML] Proteomic analysis of aqueous humor from patients with myopia

X Duan, Q Lu, P Xue, H Zhang, Z Dong, F Yang… - Molecular …, 2008 - ncbi.nlm.nih.gov
Purpose The mechanism of axial elongation in the myopic eyeball remains to be elucidated.
It is known that the expression profile for some proteins in the aqueous humor (AH) changes …