“Suffering so great as I underwent cannot be expressed in words... but the blank whirlwind of
emotion, the horror of great darkness, and the sense of desertion by God and man, which …

Nicotinic acetylcholine receptors are members of the ligand-gated ion channel superfamily,
that includes also gamma-amino-butiric-acidA, glycine, and 5-hydroxytryptamine3 receptors …

The effects of propofol (2, 6 di-isopropylphenol) on responses to the selective glutamate
receptor agonists, N-methyl-D-aspartate (NMDA) and kainate, were investigated in cultured …

Background The mechanisms of action of general anesthetics are not completely
understood. Many general anesthetics are reported to potentiate gamma-aminobutyric acid …

Background Nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of
fast neurotransmitter-gated receptor channels that includes the gamma-aminobutyric acidA …

Background It is postulated that alteration of central cholinergic transmission plays an
important role in the mechanism by which anesthetics produce unconsciousness. The …

An extensive search for isoflurane binding sites in the nicotinic acetylcholine receptor
(nAChR) and the proton gated ion channel from Gloebacter violaceus (GLIC) has been …

Myasthenia gravis, affecting neuromuscular transmission, leads to a large variability in
sensitivity to depolarising and non‐depolarising neuromuscular blocking drugs. We report …

This paper provides new insights of how general anaesthetic research should be carried out
in the future by an analysis of what we know, what we do not know and what we would like …

Volatile anesthetics enhance the neuromuscular blockade produced by nondepolarizing
muscle relaxants (NDMRs). The neuromuscular junction is a postulated site of this …