Endothelium structure and function in kidney health and disease

N Jourde-Chiche, F Fakhouri, L Dou, J Bellien… - Nature Reviews …, 2019 - nature.com
The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation

JR Liu, H Miao, DQ Deng, ND Vaziri, P Li… - Cellular and Molecular …, 2021 - Springer
The gut microbiota has a crucial effect on regulating the intestinal mucosal immunity and
maintaining intestinal homeostasis both in health and in disease state. Many effects are …

Uremic toxins: an alarming danger concerning the cardiovascular system

CA Falconi, CVC Junho, F Fogaça-Ruiz… - Frontiers in …, 2021 - frontiersin.org
The kidneys and heart share functions with the common goal of maintaining homeostasis.
When kidney injury occurs, many compounds, the so-called “uremic retention solutes” or …

Immune system dysfunction and inflammation in hemodialysis patients: two sides of the same coin

S Campo, A Lacquaniti, D Trombetta… - Journal of Clinical …, 2022 - mdpi.com
Biocompatibility in hemodialysis (HD) has considerably improved in recent decades, but
remains an open issue to be solved, appearing essential to reduce systemic inflammation …

Platelet abnormalities in CKD and their implications for antiplatelet therapy

CC Baaten, JR Schröer, J Floege, N Marx… - Clinical Journal of the …, 2022 - journals.lww.com
Patients with CKD display a significantly higher risk of cardiovascular and thromboembolic
complications, with around half of patients with advanced CKD ultimately dying of …

A bacterial chemoreceptor that mediates chemotaxis to two different plant hormones

M Rico‐Jiménez, A Roca, T Krell… - Environmental …, 2022 - Wiley Online Library
Summary Indole‐3‐acetic acid (IAA) is the main naturally occurring auxin and is produced
by organisms of all kingdoms of life. In addition to the regulation of plant growth and …

What if not all metabolites from the uremic toxin generating pathways are toxic? A hypothesis

R Vanholder, SK Nigam, S Burtey, G Glorieux - Toxins, 2022 - mdpi.com
The topic of uremic toxicity has received broad attention from the nephrological community
over the past few decades. An aspect that is much less often considered is the possibility …

Endothelial damage, inflammation and immunity in chronic kidney disease

M Diaz-Ricart, S Torramade-Moix, G Pascual… - Toxins, 2020 - mdpi.com
Chronic kidney disease (CKD) patients have an accelerated atherosclerosis, increased risk
of thrombotic-ischemic complications, and excessive mortality rates when compared with the …

[HTML][HTML] Gut microbiota and diabetic kidney diseases: Pathogenesis and therapeutic perspectives

JR Lin, ZT Wang, JJ Sun, YY Yang, XX Li… - World journal of …, 2022 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is one of the major chronic complications of diabetes mellitus
(DM), as well as a main cause of end-stage renal disease. Over the last few years …

Tryptophan-derived uremic toxins and thrombosis in chronic kidney disease

T Addi, L Dou, S Burtey - Toxins, 2018 - mdpi.com
Patients with chronic kidney disease (CKD) display an elevated risk of thrombosis.
Thrombosis occurs in cardiovascular events, such as venous thromboembolism, stroke, and …