Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

J Zou, W Yang, W Cui, C Li, C Ma, X Ji, J Hong… - Journal of …, 2023 - Springer
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

[HTML][HTML] Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury

JY Cao, B Wang, TT Tang, Y Wen, ZL Li, ST Feng… - Theranostics, 2021 - ncbi.nlm.nih.gov
Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …

[HTML][HTML] New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

CP Palanisamy, JJ Pei, P Alugoju, NVA Anthikapalli… - Theranostics, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

G Qiu, G Zheng, M Ge, J Wang, R Huang… - Stem Cell Research & …, 2018 - Springer
Mesenchymal stem cells (MSCs) are adult stromal cells with the capacity to differentiate into
multiple types of cells. MSCs represent an attractive option in regenerative medicine due to …

Hydrogel-mediated sustained systemic delivery of mesenchymal stem cell-derived extracellular vesicles improves hepatic regeneration in chronic liver failure

S Mardpour, MH Ghanian… - … applied materials & …, 2019 - ACS Publications
Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have been widely
reported as promising cell-free products that show therapeutic effects of the parental cells …

Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis

Y Jin, M Xu, H Zhu, C Dong, J Ji, Y Liu… - Journal of cellular …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) have shown chondroprotective effects in clinical models of
osteoarthritis (OA). However, effects of MSC‐derived exosomes on OA remain unclear. The …

Bone scaffolds: an incorporation of biomaterials, cells, and biofactors

M Bahraminasab, M Janmohammadi… - ACS Biomaterials …, 2021 - ACS Publications
Large injuries to bones are still one of the most challenging musculoskeletal problems.
Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in …

The clinical trials of mesenchymal stem cell therapy in skin diseases: an update and concise review

A Golchin, TZ Farahany, A Khojasteh… - Current stem cell …, 2019 - ingentaconnect.com
The skin is one of the crucial body organs with anatomy and physiology linked to various
disorders including congenital and acquired diseases. Nowadays, mesenchymal stem cell …

Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization

J Wang, J Xia, R Huang, Y Hu, J Fan, Q Shu… - Stem Cell Research & …, 2020 - Springer
Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal
tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted …