The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer

JR Inigo, D Chandra - Journal of hematology & oncology, 2022 - Springer
Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

Heat shock proteins: agents of cancer development and therapeutic targets in anti-cancer therapy

CW Yun, HJ Kim, JH Lim, SH Lee - Cells, 2019 - mdpi.com
Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by
their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90 …

Therapeutic targeting of NF-κB in acute lung injury: a double-edged sword

MW Millar, F Fazal, A Rahman - Cells, 2022 - mdpi.com
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …

HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis

Z Albakova, Y Mangasarova, A Albakov… - Frontiers in …, 2022 - frontiersin.org
HSP70 and HSP90 are two powerful chaperone machineries involved in survival and
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …

Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer

CS Palmer, AJ Anderson, D Stojanovski - FEBS letters, 2021 - Wiley Online Library
The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

The assembly of succinate dehydrogenase: a key enzyme in bioenergetics

B Moosavi, EA Berry, XL Zhu, WC Yang… - Cellular and molecular life …, 2019 - Springer
Succinate dehydrogenase (SDH) also known as complex II or succinate: quinone
oxidoreductase is an enzyme involved in both oxidative phosphorylation and tricarboxylic …

Experimental evidence for therapeutic potentials of propolis

P Bhargava, D Mahanta, A Kaul, Y Ishida, K Terao… - Nutrients, 2021 - mdpi.com
Propolis is produced by honeybees from materials collected from plants they visit. It is a
resinous material having mixtures of wax and bee enzymes. Propolis is also known as bee …

Molecular chaperones in cancer stem cells: determinants of stemness and potential targets for antitumor therapy

A Kabakov, A Yakimova, O Matchuk - Cells, 2020 - mdpi.com
Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …

Mitochondria as a novel target for cancer chemoprevention: emergence of mitochondrial-targeting agents

M Huang, CR Myers, Y Wang, M You - Cancer Prevention Research, 2021 - AACR
Cancer chemoprevention is the most effective approach to control cancer in the population.
Despite significant progress, chemoprevention has not been widely adopted because …

Therapeutic strategies of dual-target small molecules to overcome drug resistance in cancer therapy

J Ye, J Wu, B Liu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …