Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Enzymes are widely applied in various industrial applications and processes, including the
food and beverage, animal feed, textile, detergent and medical industries. Enzymes …

Protein engineering is the most important method to overcome the limitations of natural
enzymes as biocatalysts. The past few years have seen a tremendous increase in novel …

Myriad new applications of proteases would be enabled by an ability to fine-tune substrate
specificity and activity. Herein we present a general strategy for engineering protease …

Biocatalysts, especially enzymes, have the ability to catalyze reactions with high product
selectivity, utilize a broad range of substrates, and maintain activity at low temperature and …

DNA catalysts (deoxyribozymes) for a variety of reactions have been identified by in vitro
selection. However, for certain reactions this identification has not been achieved. One …

Innovations in novel enzyme discoveries impact upon a wide range of industries for which
biocatalysis and biotransformations represent a great challenge, ie, food industry, polymers …

Screening throughput is a key in directed evolution experiments and enzyme discovery.
Here, we describe a high-throughput screening platform based on a coupled reaction of …

Highlights•Inherited metabolic disorders of proteins utilize amino acid medical foods.•New
glycomacropeptide medical foods can manage well phenylketonuria and tyrosinemia.• …