Lung cancer is the leading cause of cancer-related mortality worldwide. Although the
PI3K/Akt/mTOR signaling pathway has recently been considered as one of the most altered …

Lung cancer has shown a decrease in incidence and mortality in recent decades; however,
it remains one of the cancers with the highest incidence and ranks first in cancerrelated …

Purpose: KRAS-mutant lung cancers have been recalcitrant to treatments including those
targeting the MAPK pathway. Covalent inhibitors of KRAS p. G12C allele allow for direct and …

The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …

Cancer is the leading cause of human deaths worldwide. Understanding the biology
underlying the evolution of cancer is important for reducing the economic and social burden …

Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer and a tumor
with a broad spectrum of targeted therapies already available or in clinical trials. Thus …

Proinflammatory cytokines in the tumor microenvironment can promote tumor growth, yet
their value as therapeutic targets remains underexploited. We validated the functional …

Simple Summary Biomarkers for the prediction and efficacy of therapies are an urgent
necessity for lung cancer patients. In this article, we summarize genomic and proteomic …

Lung cancer (LC) represents the second most diagnosed tumor and the malignancy with the
highest mortality rate. In recent years, tremendous progress has been made in the treatment …

Purpose Non-small cell lung cancer (NSCLC) accounts for about 85% in all cases of lung
cancer. In recent years, molecular targeting drugs for NSCLC have been developed rapidly …