Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …

Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in
a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly …

Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …

Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-
dependent oxidoreductase residing in the mitochondrial intermembrane space whose …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in multiple neurologic
diseases by mediating caspase-independent cell death, which has recently been …

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic
function, is required for the normal expression of major respiratory chain complexes. Here …

Pediatric cancers are the driving cause of death for children and adolescents. Due to safety
requirements and considerations, treatment strategies and drugs for pediatric cancers have …

Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate
citrullination, an irreversible post-translational modification (PTM). PAD enzymes have …