Advanced strategies for production of natural products in yeast

R Chen, S Yang, L Zhang, YJ Zhou - Iscience, 2020 - cell.com
Natural products account for more than 50% of all small-molecule pharmaceutical agents
currently in clinical use. However, low availability often becomes problematic when a …

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Identifying and engineering the ideal microbial terpenoid production host

S Moser, H Pichler - Applied Microbiology and Biotechnology, 2019 - Springer
More than 70,000 different terpenoid structures are known so far; many of them offer highly
interesting applications as pharmaceuticals, flavors and fragrances, or biofuels. Extraction of …

[HTML][HTML] Modular engineering for microbial production of carotenoids

C Li, CA Swofford, AJ Sinskey - Metabolic Engineering Communications, 2020 - Elsevier
There is an increasing demand for carotenoids due to their applications in the food, flavor,
pharmaceutical and feed industries, however, the extraction and synthesis of these …

Microbial Platform for Terpenoid Production: Escherichia coli and Yeast

C Wang, M Liwei, JB Park, SH Jeong, G Wei… - Frontiers in …, 2018 - frontiersin.org
Terpenoids, also called isoprenoids, are a large and highly diverse family of natural
products with important medical and industrial properties. However, a limited production of …

Chemicals from lignocellulosic biomass: a critical comparison between biochemical, microwave and thermochemical conversion methods

IKM Yu, H Chen, F Abeln, H Auta, J Fan… - Critical Reviews in …, 2021 - Taylor & Francis
The past decades have seen an increasing interest in developing pathways to produce bio-
based chemicals from lignocellulosic biomass and organic waste as renewable resources …

Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply

Q Wang, S Quan, H Xiao - Bioresources and Bioprocessing, 2019 - Springer
Terpenoids are a group of largest natural products with important biological functions, and
their efficient biosynthesis is of particular importance to both academia and industry. As the …

[HTML][HTML] Optimizing microbial networks through metabolic bypasses

E Orsi, NJ Claassens, PI Nikel, SN Lindner - Biotechnology Advances, 2022 - Elsevier
Metabolism has long been considered as a relatively stiff set of biochemical reactions. This
somewhat outdated and dogmatic view has been challenged over the last years, as multiple …

Construction and optimization of nonclassical isoprenoid biosynthetic pathways in yeast peroxisomes for (+)-valencene production

C Cao, H Zhang, X Cao, S Kong, B Zhu… - Journal of Agricultural …, 2023 - ACS Publications
Isoprenoids are a kind of natural product with various activities, but their plant extraction
suffers low concentration. The rapid development of synthetic biology offers a sustainable …

Plant aromatic prenyltransferases: tools for microbial cell factories

WJC de Bruijn, M Levisson, J Beekwilder… - Trends in …, 2020 - cell.com
In plants, prenylation of aromatic compounds, such as (iso) flavonoids and stilbenoids, by
membrane-bound prenyltransferases (PTs), is an essential step in the biosynthesis of many …