The interconnection between hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease—the transition from an adipocentric to liver …

M Vesković, N Šutulović, D Hrnčić… - Current issues in …, 2023 - mdpi.com
The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …

Nobiletin promotes lipolysis of white adipose tissue in a circadian clock-dependent manner

X Li, R Zhuang, Z Lu, F Wu, X Wu, K Zhang… - The Journal of …, 2024 - Elsevier
Nobiletin has been reported to protect against obesity-related metabolic disorders by
enhancing the circadian rhythm; however its effects on lipid metabolism in adipose tissue …

Screening of active components in Astragalus mongholicus Bunge and Panax notoginseng formula for anti-fibrosis in CKD: nobiletin inhibits Lgals1/PI3K/AKT …

F Yang, T Li, X Zhang, Y Gong, H Su, J Fan, L Wang… - Renal …, 2024 - Taylor & Francis
Abstract The Astragalus mongholicus Bunge and Panax notoginseng formula (A&P) has
been clinically shown to effectively slow down the progression of chronic kidney disease …

Anti-adipogenic properties of clock activator chlorhexidine and a new derivative

X Xiong, T Kiperman, W Li, Z Fang, A Agua, W Huang… - bioRxiv, 2023 - biorxiv.org
Background: The circadian clock exerts temporal control of metabolic pathways to maintain
homeostasis, and its disruption leads to the development of obesity and insulin resistance …