Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder with an unknown
cause characterized by high-spiking fever, lymphadenopathy, hepatosplenomegaly …

Natural soluble antagonist and decoy receptor on the surface of the cell membrane are
evolving as crucial immune system regulators as these molecules are capable of …

Background/objectives Long-term efficacy and safety of tocilizumab (TCZ) in adult-onset
Still's disease (AOSD) mostly derive from small case series. Herein we report a registry …

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine that is involved in various innate
and adaptive immune processes related to infection, inflammation, and autoimmunity …

Introduction Currently, the therapeutic management of Still's disease, a multisystemic
inflammatory rare disorder, is directed to target the inflammatory symptoms and signs of …

Adult-onset Still's disease (AOSD) is a multisystemic complex disorder clinically
characterised by episodes of spiking fever, evanescent rash, polyarthritis or diffuse …

The immune system provides 2 layers, innate and adaptive, of defense against pathogenic
organisms or endogenous dangers. Normally, the innate immune response is rapid (minutes …

Objectives Still's disease is a rare autoinflammatory disorder characterized by systemic
inflammation, fever, rash, and arthritis. The term “Still's disease” covers the pediatric subtype …

This work aimed to investigate a potential link between serum IL-1β levels in patients with
giant cell arteritis (GCA) and their responsiveness to combined anti-IL-6 receptor (IL-6R) and …

Epidemiologie Das Still-Syndrom kann sich vom Kindes-bis ins höhere Erwachsenenalter
manifestieren–mit jeweils leicht unterschiedlicher klinischer Ausprägung. Pathogenese Das …