Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review
the essential immunologic concepts underpinning natural immunity and highlight the …

The physical energy activated techniques for cellular delivery and analysis is one of the
most rapidly expanding research areas for a variety of biological and biomedical …

GBM is the most aggressive and common form of primary brain cancer with a dismal
prognosis. Current GBM treatments have not improved patient survival, due to the propensity …

Activation of T cell responses is essential for effective tumor clearance; however, inducing
targeted, potent antigen presentation to stimulate T cell responses remains challenging. We …

Small extracellular vesicles (sEVs) are recognized as promising detection biomarkers and
attractive delivery vehicles, showing great potential in diagnosis and treatment of diseases …

We conducted a dose escalation Phase 1 study of autologous PBMCs loaded by microfluidic
squeezing (Cell Squeeze® technology) with HPV16 E6 and E7 antigens (SQZ-PBMC-HPV) …

Genetic reprogramming of immune cells to recognize and target tumor cells offers a
possibility of long-term cure. Cell therapies, however, lack simple and affordable …

The cancer‐immunity cycle is a fundamental framework for understanding how the immune
system interacts with cancer cells, balancing T cell recognition and elimination of tumors …

Immunomechanobiology, the study of how physical forces influence the behavior and
function of immune cells, is a rapidly growing area of research. It is becoming increasingly …

Despite the availability of prophylactic human papillomavirus (HPV) vaccines, there is a
growing incidence of HPV-associated head and neck squamous cell carcinomas (HPV …