The person-to-person transmission landscape of the gut and oral microbiomes

M Valles-Colomer, A Blanco-Míguez, P Manghi… - Nature, 2023 - nature.com
The human microbiome is an integral component of the human body and a co-determinant
of several health conditions,. However, the extent to which interpersonal relations shape the …

Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases

G Ianiro, M Punčochář, N Karcher, S Porcari… - Nature Medicine, 2022 - nature.com
Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides
difficile infection and is considered a promising treatment for other microbiome-related …

Drivers and determinants of strain dynamics following fecal microbiota transplantation

TSB Schmidt, SS Li, OM Maistrenko, W Akanni… - Nature medicine, 2022 - nature.com
Fecal microbiota transplantation (FMT) is a therapeutic intervention for inflammatory
diseases of the gastrointestinal tract, but its clinical mode of action and subsequent …

Identification of clinical and ecological determinants of strain engraftment after fecal microbiota transplantation using metagenomics

D Podlesny, M Durdevic, S Paramsothy… - Cell Reports …, 2022 - cell.com
Fecal microbiota transplantation (FMT) is a promising therapeutic approach for microbiota-
associated pathologies, but our understanding of the post-FMT microbiome assembly …

Transient suppression of bacterial populations associated with gut health is critical in success of exclusive enteral nutrition for children with Crohn's disease

J Runde, I Veseli, EC Fogarty… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims Exclusive enteral nutrition [EEN] is a dietary intervention to
induce clinical remission in children with active luminal Crohn's disease [CD]. While …

Metagenomic strain detection with SameStr: identification of a persisting core gut microbiota transferable by fecal transplantation

D Podlesny, C Arze, E Dörner, S Verma, S Dutta… - Microbiome, 2022 - Springer
Background The understanding of how microbiomes assemble, function, and evolve
requires metagenomic tools that can resolve microbiota compositions at the strain level …

Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults

BA Siranosian, EF Brooks, T Andermann… - Nature …, 2022 - nature.com
Bacterial bloodstream infections are a major cause of morbidity and mortality among
patients undergoing hematopoietic cell transplantation (HCT). Although previous research …

Single-colony sequencing reveals microbe-by-microbiome phylosymbiosis between the cyanobacterium Microcystis and its associated bacteria

OM Pérez-Carrascal, N Tromas, Y Terrat, E Moreno… - Microbiome, 2021 - Springer
Background Cyanobacteria from the genus Microcystis can form large mucilaginous
colonies with attached heterotrophic bacteria—their microbiome. However, the nature of the …

Functional profile of host microbiome indicates Clostridioides difficile infection

E Nzabarushimana, H Tang - Gut Microbes, 2022 - Taylor & Francis
Clostridioides difficile infection (CDI) is a gastro-intestinal (GI) infection that illustrates how
perturbations in symbiotic host–microbiome interactions render the GI tract vulnerable to the …

Scalable microbial strain inference in metagenomic data using StrainFacts

BJ Smith, X Li, ZJ Shi, A Abate… - Frontiers in Bioinformatics, 2022 - frontiersin.org
While genome databases are nearing a complete catalog of species commonly inhabiting
the human gut, their representation of intraspecific diversity is lacking for all but the most …