The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …

In this paper, we propose DeCoST (Drug Repurposing from Control System Theory)
framework to apply control system paradigm for drug repurposing purpose. Drug …

Background Hypertension is associated with the risk of prostate cancer (PCa) and its
progression, however, it remains unclear whether antihypertensive medicines alter PCa risk …

Despite radiotherapy is an effective regimen in cancer treatment, resistance to tumor therapy
still is a major challenge to radiotherapy and results in cancer recurrence and metastasis …

Tumour cells may be resistant to radiotherapy that results in unsuccessful cancer treatment
in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) …

Metronomic chemotherapy refers to the minimum biologically effective doses of a
chemotherapy agent given as a continuous regimen without extended rest periods. Drug …

Radiotherapy is a cancer treatment protocol which delivers high dose of ionizing radiation
(IR) to tumor. Tumor resistance and side effects induced by IR still are the major challenges …

The main contributions in this thesis include the selectively decentralized method in solving
multi-agent reinforcement learning problems and the discretized Markov-decision-process …