Bioorthogonal Chemistry in Translational Research: Advances and Opportunities

R Chaudhuri, S Bhattacharya, J Dash - ChemBioChem, 2023 - Wiley Online Library
Bioorthogonal chemistry is a rapidly expanding field of research that involves the use of
small molecules that can react selectively with biomolecules in living cells and organisms …

Sydnthiones are versatile bioorthogonal hydrogen sulfide donors

W Xu, C Tang, R Zhao, Y Wang, H Jiao, H Ang… - Nature …, 2024 - nature.com
Hydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the bioorthogonal
reaction triggered H2S donors are still rare. Here we show one type of bioorthogonal H2S …

Demolish and rebuild: controlling lipid self-assembly toward triggered release and artificial cells

ML Qualls, R Sagar, J Lou, MD Best - The Journal of Physical …, 2021 - ACS Publications
The ability to modulate the structures of lipid membranes, predicated on our nuanced
understanding of the properties that drive and alter lipid self-assembly, has opened up many …

Development of Radiolabeled Probes with Improved Imaging Contrast by Releasing Urinary Excretable Radiolabeled Compounds from Thermosensitive Liposomes …

M Munekane, M Ozaki, Y Mitani, N Sakaida… - Molecular …, 2024 - ACS Publications
In this study, thermosensitive liposomes (TSLs) encapsulating urinary excretable
radiolabeled compounds were developed. We considered that the release of the …

Enhanced Therapeutic Effect of Liposomal Doxorubicin via Bio-Orthogonal Chemical Reactions in Tumors

K Kannaka, K Sano, M Munekane… - Molecular …, 2022 - ACS Publications
Liposomes are highly biocompatible drug carriers in drug delivery systems (DDSs).
Preferential accumulation of liposomes and acceleration of drug release at target tumor sites …

Investigation of mitochondrial targeting ability of sydnones and sydnonimines and mitochondria-targeted delivery of celecoxib

W Xu, H Yu, R Zhao, Y Liang - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Mitochondria are considered to be a promising target in cancer diagnosis and therapeutics.
Recently, sydnone and sydnonimine, as mesoionic bioorthogonal reagents, have been used …

[HTML][HTML] Combination of transcatheter arterial chemoembolization and anti-PD-L1 liposomes therapy suppressed hepatocellular carcinoma progression in mice

J Li, L Zhang, Y Tao, Z Sun, Y Ge, S Hu - European Journal of …, 2023 - Elsevier
Background Hepatocellular carcinoma (HCC) is a serious life-threatened tumor with high
morbidity and mortality. This study aimed to study the effects of combination TACE and anti …

Inverse Electron Demand Diels–Alder Reactions in the Liposomal Membrane Accelerates Release of the Encapsulated Drugs

K Kannaka, K Sano, H Nakahara, M Munekane… - Langmuir, 2020 - ACS Publications
Bio-orthogonal inverse electron demand Diels–Alder (IEDDA) reactions between liposomes
containing a tetrazine-based (Tz) compound and 2-norbornene (2-NB) could be a novel …

Preparation and Evaluation of Thermosensitive Liposomes Encapsulating I-125-Labeled Doxorubicin Derivatives for Auger Electron Therapy

MEN Elghobary, M Munekane, K Mishiro, T Fuchigami… - Molecules, 2023 - mdpi.com
Auger electrons (AEs) are very low-energy electrons emitted by radionuclides such as I-125
(125I). This energy is deposited across a small distance (< 0.5 μm), resulting in high linear …

Preparation and evaluation of 111In-labeled liposomes containing phosphatidylglycerol for detection of macrophages in atherosclerotic plaques

M Munekane, H Mori, N Takada, K Sano… - Nuclear Medicine and …, 2023 - Elsevier
Macrophage infiltration is a characteristic feature of atherosclerotic plaque progression.
Since liposomes containing 1, 2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) are …