Highlights•Trained immunity is induced in a variety of innate immune cell types.•Central and
peripheral trained immunity underlies the long-term effects of innate immunity.•Metabolic …

Trained immunity is a long-term increase in responsiveness of innate immune cells, induced
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic …

This proof-of-concept study tested if prior BCG revaccination can qualitatively and
quantitively enhance antibody and T-cell responses induced by Oxford/AstraZeneca …

The observation of reduced COVID-19 incidence and severity in populations receiving
neonatal intradermal BCG vaccination vaccine raised the question of whether BCG can …

Summary Bacillus Calmette-Guérin (BCG) confers heterologous immune protection against
viral infections and has been proposed as vaccine against SARS-CoV-2 (SCV2). Here, we …

Abstract Background The bacille Calmette–Guérin (BCG) vaccine has immunomodulatory
“off-target” effects that have been hypothesized to protect against coronavirus disease 2019 …

Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these
diseases, tuberculosis (TB), a bacterial illness caused by Mycobacterium tuberculosis which …

The development of new therapies against SARS-CoV-2 is required to extend the toolkit of
intervention strategies to combat the global pandemic. In this study, hyperimmune plasma …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
the coronavirus disease 2019 (COVID-19), and its variants have brought unprecedented …

The bacillus Calmette–Guérin (BCG) is an attenuated bacterium derived from virulent
Mycobacterium bovis. It is the only licensed vaccine used for preventing severe forms of …