Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

SHERLOCK and DETECTR: CRISPR-Cas systems as potential rapid diagnostic tools for emerging infectious diseases

MI Mustafa, AM Makhawi - Journal of Clinical Microbiology, 2021 - Am Soc Microbiol
Infectious diseases are one of the most intimidating threats to human race, responsible for
an immense burden of disabilities and deaths. Rapid diagnosis and treatment of infectious …

Viral vector-based gene therapy

X Li, Y Le, Z Zhang, X Nian, B Liu, X Yang - International Journal of …, 2023 - mdpi.com
Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

RNA-targeting CRISPR–Cas systems and their applications

M Burmistrz, K Krakowski… - International journal of …, 2020 - mdpi.com
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)–CRISPR-associated
(Cas) systems have revolutionized modern molecular biology. Numerous types of these …

Technological aspects of manufacturing and analytical control of biological nanoparticles

S Brezgin, A Parodi, A Kostyusheva… - Biotechnology …, 2023 - Elsevier
Extracellular vesicles (EVs) are cell-derived biological nanoparticles that gained great
interest for drug delivery. EVs have numerous advantages compared to synthetic …

Lipid-nanoparticle-based delivery of CRISPR/Cas9 genome-editing components

P Kazemian, SY Yu, SB Thomson… - Molecular …, 2022 - ACS Publications
Gene editing mediated by CRISPR/Cas9 systems is due to become a beneficial therapeutic
option for treating genetic diseases and some cancers. However, there are challenges in …

CRISPR-Cas systems for diagnosing infectious diseases

A Kostyusheva, S Brezgin, Y Babin, I Vasilyeva… - Methods, 2022 - Elsevier
Infectious diseases are a global health problem affecting billions of people. Developing
rapid and sensitive diagnostic tools is key for successful patient management and curbing …

[HTML][HTML] CRISPR: History and perspectives to the future

Z Kozovska, S Rajcaniova, P Munteanu… - Biomedicine & …, 2021 - Elsevier
This review summarizes the information about the history and future of the CRISPR/Cas9
method. Genome editing can be perceived as a group of technologies that allow scientists to …

[HTML][HTML] Advances in genomics and genome editing for breeding next generation of fruit and nut crops

S Savadi, S Mangalassery, MS Sandesh - Genomics, 2021 - Elsevier
Fruit tree crops are an essential part of the food production systems and are key to achieve
food and nutrition security. Genetic improvement of fruit trees by conventional breeding has …

Engineered mRNA delivery systems for biomedical applications

J Wang, H Zhu, J Gan, G Liang, L Li… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapeutic strategies have shown remarkable promise in
preventing and treating a staggering range of diseases. Optimizing the structure and …