Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
Crosstalk between PTEN/PI3K/Akt signalling and DNA damage in the oocyte: implications for primordial follicle activation, oocyte quality and ageing
The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …
A p53–phosphoinositide signalosome regulates nuclear AKT activation
The tumour suppressor p53 and PI3K–AKT pathways have fundamental roles in the
regulation of cell growth and apoptosis, and are frequently mutated in cancer. Here, we …
regulation of cell growth and apoptosis, and are frequently mutated in cancer. Here, we …
53BP1: A key player of DNA damage response with critical functions in cancer
M Mirza-Aghazadeh-Attari, A Mohammadzadeh… - DNA repair, 2019 - Elsevier
Maintenance of genome integrity and stability is a critical responsibility of the DNA damage
response (DDR) within cells, such that any disruption in this kinase-based signaling …
response (DDR) within cells, such that any disruption in this kinase-based signaling …
New insights into protein kinase B/Akt signaling: role of localized Akt activation and compartment-specific target proteins for the cellular radiation response
K Szymonowicz, S Oeck, NM Malewicz, V Jendrossek - Cancers, 2018 - mdpi.com
Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …
are observed with high frequency during malignant transformation and cancer progression …
The ubiquitin codes in cellular stress responses
Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications,
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …
K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair
Polyubiquitylation is canonically viewed as a posttranslational modification that governs
protein stability or protein-protein interactions, in which distinct polyubiquitin linkages …
protein stability or protein-protein interactions, in which distinct polyubiquitin linkages …
FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4
Q Zhang, D Karnak, M Tan, TS Lawrence, MA Morgan… - Molecular cell, 2016 - cell.com
FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in
human cancers. FBXW7 inactivation causes genomic instability, but the mechanism remains …
human cancers. FBXW7 inactivation causes genomic instability, but the mechanism remains …
Peroxisome proliferator-activated receptors and caloric restriction—common pathways affecting metabolism, health, and longevity
Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health
and increasing lifespan. CR exerts its effects through multiple molecular pathways that …
and increasing lifespan. CR exerts its effects through multiple molecular pathways that …
C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
R Bhargava, M Sandhu, S Muk, G Lee… - Nature …, 2018 - nature.com
To investigate the fidelity of canonical non-homologous end joining (C-NHEJ), we
developed an assay to detect EJ between distal ends of two Cas9-induced chromosomal …
developed an assay to detect EJ between distal ends of two Cas9-induced chromosomal …