In a state of balance between oxidants and antioxidants, free radicals play an advantageous
role of “redox messengers”. In a state of oxidative stress, they trigger a cascade of events …

Epilepsy is a common neurological disorder which affects patients physically and mentally
and causes a real burden for the patient, family and society both medically and …

Chronic, sustained inflammation underlies many pathological conditions, including
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …

Necroptosis is a kind of programmed cell death that causes the release of damage-
associated molecular patterns and inflammatory disease including skin inflammation …

Neuroinflammation is a critical pathophysiological hallmark of neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and traumatic brain injury …

Abstract Ethnopharmacological relevance Tetrastigma hemsleyanum Diels et Gilg (T.
hemsleyanum, Sanyeqing) has been used in the prevention and treatment of repetitive …

Traumatic brain injury (TBI) is a leading cause of death in young adults and a risk factor for
acquired epilepsy. Severe TBI, after a period of time, causes numerous neuropsychiatric and …

Fyn is a non-receptor tyrosine kinase belonging to the Src family of kinases (SFKs) which
has been implicated in several integral functions throughout the central nervous system …

Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …

Both Fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in
many tauopathies, including Alzheimer's disease (AD). Individual genetic ablation of fyn or …