Surface plasmon resonance (SPR) is a label-free detection method by which molecular
interactions may be analyzed on a surface. Binding data are collected in real time, allowing …

High-throughput DNA de novo synthesis has drawn extensive attention from academia and
bioindustry due to its fundamental importance in applications such as gene synthesis, drug …

Glass is by far the most common substrate for biomolecular arrays, including high-
throughput sequencing flow cells and microarrays. The native glass hydroxyl surface is …

Fluorescein is commonly used to label macromolecules, particularly proteins and nucleic
acids, but its fluorescence is known to be strongly dependent on its direct chemical …

Nucleic acids attached to electrically conductive surfaces are very frequently used platforms
for sensing and analyte detection as well as for imaging. Synthesizing DNA on these …

Fluorescence is an ideal tool to see and manipulate nucleic acids, and engage in their rich
and complex biophysical properties. Labeling is the preferred approach to track and quantify …

Background Light-directed in situ synthesis of DNA microarrays using computer-controlled
projection from a digital micromirror device--maskless array synthesis (MAS)--has proved to …

RNA catalytic and binding interactions with proteins and small molecules are fundamental
elements of cellular life processes as well as the basis for RNA therapeutics and molecular …

Thermoplastic materials such as cyclic-olefin copolymers (COC) provide a versatile and cost-
effective alternative to the traditional glass or silicon substrate for rapid prototyping and …

Formation of functional monolayers on surfaces of carbon materials is inherently difficult
because of the high bond strength of carbon and because common pathways such as SN2 …