Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Importance Experimental data suggest that intravenous vitamin C may attenuate
inflammation and vascular injury associated with sepsis and acute respiratory distress …

Following the new ESPEN Standard Operating Procedures, the previous guidelines to
provide best medical nutritional therapy to critically ill patients have been updated. These …

Abstract As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019)
pandemic has swept through 213 countries and infected more than 1,870,000 individuals …

Background Few specific medications have been proven effective for the treatment of
patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high …

Abstract Pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge …

Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective
than hydrocortisone alone in expediting resolution of septic shock. Objective To determine …