Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …

Tissue fibrosis is characterized by uncontrolled deposition and diminished clearance of
fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated …

Persistent myofibroblast activation distinguishes pathological fibrosis from physiological
wound healing, suggesting that therapies selectively inducing myofibroblast apoptosis could …

Systemic sclerosis (SSc) is a severe auto-immune disease, characterized by vasculopathy
and fibrosis of connective tissues. SSc has a high morbidity and mortality and unfortunately …

The transforming growth factor-beta (TGF-!) belongs to a superfamily of cytokines that act on
protein kinase receptors at the plasma membrane to induce a plethora of biological signals …

Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis.
Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue …

Objective Enhanced adhesive signaling, including activation of focal adhesion kinase (FAK),
is a hallmark of fibroblasts from lung fibrosis patients, and FAK has therefore been …

Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment
options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera; Biogen …