In vitro validation of the therapeutic potential of dendrimer-based nanoformulations against tumor stem cells

N Knauer, V Arkhipova, G Li, M Hewera… - International Journal of …, 2022 - mdpi.com
Tumor cells with stem cell properties are considered to play major roles in promoting the
development and malignant behavior of aggressive cancers. Therapeutic strategies that …

Rapid, label-free classification of glioblastoma differentiation status combining confocal Raman spectroscopy and machine learning

LM Wurm, B Fischer, V Neuschmelting, D Reinecke… - Analyst, 2023 - pubs.rsc.org
Label-free identification of tumor cells using spectroscopic assays has emerged as a
technological innovation with a proven ability for rapid implementation in clinical care …

WNT/β-catenin-mediated resistance to glucose deprivation in glioblastoma stem-like cells

S Yusuf, P Aretz, AC Nickel, P Westhoff, A Sharma… - Cancers, 2022 - mdpi.com
Simple Summary The malignant growth and therapy resistance of isocitrate dehydrogenase
(IDH)-wildtype glioblastoma is thought to be driven by a subpopulation of tumor cells with …

Amphiphilic triazine-phosphorus metallodendrons possessing anti-cancer stem cell activity

EK Apartsin, N Knauer, UD Kahlert, AM Caminade - Pharmaceutics, 2022 - mdpi.com
Dendritic molecules bearing metal complexes in their structure (metallodendrimers and
metallodendrons) are considered prospective therapeutic entities. In particular …

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo

R Du, AY Sanin, W Shi, B Huang, AC Nickel… - Frontiers in …, 2024 - frontiersin.org
Glioblastoma (GBM) is the most commonly occurring and most aggressive primary brain
tumor. Transcriptomics-based tumor subtype classification has established the …

Rapid and reproducible generation of glioblastoma spheroids for high-throughput drug screening

C Bach, A Glasow, R Baran-Schmidt… - … in Bioengineering and …, 2024 - frontiersin.org
Identifying new substances that could potentially be used for tumor therapy and the precise
analysis of their spectrum of action requires models that are as similar as possible to the …

Progenitor cells derived from gene‐engineered human induced pluripotent stem cells as synthetic cancer cell alternatives for in vitro pharmacology

C Uhlmann, AC Nickel, D Picard, A Rossi… - Biotechnology …, 2022 - Wiley Online Library
Limitations in genetic stability and recapitulating accurate physiological disease properties
challenge the utility of patient‐derived (PD) cancer models for reproducible and translational …

[HTML][HTML] Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells

DM Ouwens, M Hewera, G Li, W Di… - Frontiers in Bioscience …, 2022 - imrpress.com
Background: The conserved stem cell signaling network canonical Wingless (WNT) plays
important roles in development and disease. Aberrant activation of this pathway has been …

[PDF][PDF] Study on the therapeutic mechanism of Tumor Treating Fields (TTFields) and Trihexyphenidyl (THP) and identification of clinical predictive expression signature …

R Du - 2023 - docserv.uni-duesseldorf.de
Glioblastoma (GBM) is the most common primary brain tumor with has a median survival of
only 14 months. Currently, surgery and postoperative adjuvant chemoradiotherapy remain …

[PDF][PDF] Amphiphilic Triazine-Phosphorus Metallodendrons Possessing Anti-Cancer Stem Cell Activity. Pharmaceutics 2022, 14, 393

EK Apartsin, N Knauer, UD Kahlert, AM Caminade - 2022 - researchgate.net
Dendritic molecules bearing metal complexes in their structure (metallodendrimers and
metallodendrons) are considered prospective therapeutic entities. In particular …