ATP-binding cassette (ABC) transporters are membrane-spanning proteins involved in
cholesterol homeostasis, transport of various molecules in and out of cells and organelles …

The ATP-binding cassette (ABC) and solute carrier (SLC) transporters are critical
determinants of drug disposition, clinical efficacy, and toxicity as they specifically mediate …

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast
to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is …

Abstract Background Single nucleotide polymorphisms (SNPs) play a significant role in
differences in individual's susceptibility to diseases, and it is imperative to differentiate …

Single-nucleotide polymorphisms (SNPs) are the most common genetic variations for
various complex human diseases, including cancers. Genome-wide association studies …

In humans, the dimeric receptor complex IFNAR2-IFNAR1 accelerates cellular response
triggered by type I interferon (IFN) family proteins in response to viral infection including …

Due to the high prevalence of cancer, progress in the management of cancer is the need of
the hour. Most cancer patients develop chemotherapeutic drug resistance, and many remain …

Background Therapeutic failure and drug resistance are common and have important
implications in the poor prognosis of advanced breast cancer. It is necessary to acquire a …

Melanoma is a type of skin cancer. Numerous genes and their proteins are strongly
associated with melanoma susceptibility. This study aims to use an in silico method to …

This study investigates the effects of Mentha longifolia L. and the chemotherapeutic drug
docetaxel on drug resistance in colon cancer. One of the major challenges in colon cancer …