Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Toxic effects of fluoride on organisms

H Zuo, L Chen, M Kong, L Qiu, P Lü, P Wu, Y Yang… - Life sciences, 2018 - Elsevier
Accumulation of excess fluoride in the environment poses serious health risks to plants,
animals, and humans. This endangers human health, affects organism growth and …

Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling

M Suzuki, C Bandoski, JD Bartlett - Free Radical Biology and Medicine, 2015 - Elsevier
Fluoride is an effective caries prophylactic, but at high doses can also be an environmental
health hazard. Acute or chronic exposure to high fluoride doses can result in dental enamel …

Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways

W Li, B Jiang, X Cao, Y Xie, T Huang - Chemico-biological interactions, 2017 - Elsevier
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress.
Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To …

Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease

S Carvajal, M Perramón, D Oró, E Casals… - Scientific reports, 2019 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium …

Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells

FJ Aulestia, J Groeling, GHS Bomfim, V Costiniti… - Science …, 2020 - science.org
Fluoride ions are highly reactive, and their incorporation in forming dental enamel at low
concentrations promotes mineralization. In contrast, excessive fluoride intake causes dental …

Effects of fluoride exposure on mitochondrial function: energy metabolism, dynamics, biogenesis and mitophagy

SH Avila-Rojas, OE Aparicio-Trejo… - Environmental …, 2022 - Elsevier
Fluoride is ubiquitous in the environment. Furthermore, drinking water represents the main
source of exposure to fluoride for humans. Interestingly, low fluoride concentrations have …

[HTML][HTML] The role of FGF9-mediated TGF-β1/Smad signaling in enamel hypoplasia induced by exposure to fluoride and SO2 in rats

Y Lv, Y Wang, J Yao, J He, C Lin, G Bai, C Tu - … and Environmental Safety, 2023 - Elsevier
Many geographical areas of the world are polluted by both fluoride and sulfur dioxide (SO
2). However, the effects of simultaneous exposure to fluoride and SO 2 on teeth are …

Fluoride Affects Enamel Protein Content via TGF-β1-mediated KLK4 Inhibition

M Suzuki, M Shin, JP Simmer… - Journal of dental …, 2014 - journals.sagepub.com
Dental fluorosis is caused by chronic high-level fluoride (F–) exposure during enamel
development, and fluorosed enamel has a higher than normal protein content. Matrix …

Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation

M Suzuki, A Ikeda, JD Bartlett - Archives of toxicology, 2018 - Springer
Low-dose fluoride is an effective caries prophylactic, but high-dose fluoride is an
environmental health hazard that causes skeletal and dental fluorosis. Treatments to prevent …